Project background and description: The research group of Prof Jochen Prehn at the Centre for Systems Medicine and the Department of Physiology and Medical Physics investigates cell fate decisions. The mission of the Centre for Systems Medicine is to provide a translational research environment to identify signalling processes implicated in human disease and to utilize systems biology and mathematical approaches in combination with quantitative experimentation in order to develop new prognostic tools for the treatment of cancer. The research infrastructure of the Centre includes a team of systems biologists, clinical researcher, preclinical animal researcher and cell biology researchers, as well as state-of-the-art instrumentation including RPPA and protein arrays, Cellomics, high throughput Flow Cytometry,  single cell microscopy, two-photon intravital microscopy and small animal bioluminescence and PET/CT facilities.

Angiogenesis inhibitors show beneficial effects for the treatment of advanced  cancers, however the effects of angiogenesis inhibitor such as anti-VEGF monoclonal antibodies can vary significantly between patients. As part of the FP7 ANGIO-PREDICT consortium activities, we lead the Work Package responsible for the development of computational models of tumour growth in relation to endothelial cell proliferation, tissue hypoxia/ischemia, and cancer cell survival. We now wish to appoint a systems biologist who will further develop computational models of cell survival and apoptosis signal transduction pathways in cancer and endothelial cells previously developed by our group, using multivariate statistics, ODE/PDE/Boolean-pathway modelling and tissue-based cellular automata.  Model predictions will be validated in house using pre-clinical approaches.

The position will be available from December 1st, 2012, or January 1st, 2013.

Person Specification: The candidate should have a PhD in Bioinformatics, Systems Biology, Software Engineering or a related field, with programming experience in at least one higher programming language (C/C++, Visual Basic or MATLAB preferred). (S)he should have research experience or background knowledge in the subject areas described above, and should have demonstrated research accomplishments documented by publications and/or awards. (S)he will be required to work independently and to integrate into a strongly interdisciplinary research environment. Good communication skills are required to team up with project partners.

Salary: The successful candidate will be appointed on the salary scale at a point commensurate with qualifications and experience.

Application procedure: Please send a CV and accompanying documentation (certificates, publications) to jprehn@rcsi.ie

Closing date: Applications are reviewed at an ongoing basis but should be  received no later than Oct 31st, 2012.

Other information: Further details can be obtained from the Project Leader, Prof Jochen Prehn at prehn@rcsi.ie .

http://www.systemsmedicineireland.ie/

Prof Jochen Prehn

prehn@rcsi.ie

Centre for Systems Medicine, Royal College of Surgeons in Ireland

Dublin, Ireland

Ansprechpartner: Prof Jochen Prehn