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Postdocs in (1) bioinformatics, and (2) mouse genetics or molecular biology. Genome regulation and diabetes: Barcelona, Spain

Centre Esther Koplowitz, IDIBAPS, Barcelona

The Beta Cell Genome Regulation lab in IDIBAPS offers two postdoctoral positions for motivated scientists interested in studying genome regulation in pancreatic islets.

1. Postdoc in Computational Biology. This post aims to attract a computational biologist to work on the analysis of existing epigenomic datasets to understand how genetic variation impacts genome regulatory mechanisms. An alternative area is the analysis of genome-wide data from genetic models that aim to understand epigenetic regulation of pancreas development, function and disease. New projects that are aligned with the lab's interests will be considered, as well as collaborations with other lab members.

Applicants with diverse educational backgrounds are welcome to apply for this position but a solid computing background is essential. Knowledge of a programming language (e.g Python, C/C++, Perl, R, MatLab) is required as well as background in statistical analysis. Expertise in either epigenomics or genome-wide statistical genetic analysis is also required

2. Postdoc in gene regulation. The successful candidate will lead a project focused on understanding epigenetic mechanisms in pancreatic beta cells relevant to the pathogenesis of human disease. Two projects are available to achieve this, including studying an existing unpublished mouse genetic model that has been generated by the team, and deploying CRISPR-Cas9 methods implemented in the lab to engineer epigenetic and genetic alteration in human cell lines. It is also possible for the postdoctoral scientist to propose new projects that are aligned with the lab's interests, as well as engaging in collaborative projects with other lab members.

The lab is interested in this area to understand genomic mechanisms of disease. We are a group of computational and experimental biologists, often engaging in cross-disciplinary interactions.

The host lab interests include:
- Non-coding genome function in development and disease (see Weedon et al, Nature Genetics 2014, Pasquali et al, Nature Genetics 2014, Cebola et al Nat Cell Biol 2015),
- Long non-coding RNAs (Moran et al, Cell Metab 2012, Akerman et al, Cell Metab 2015)
- Developmental programming of pancreatic lineages (van Arensbergen et al, Genome Res 2010 and Genes and Dev, 2013; Solar et al, Dev Cell 2009).

The team is led by Jorge Ferrer, and is highly multidisciplinary, with members that have expertise in computational biology, chromatin biology, developmental biology and genetics. The successful candidate will work lab members in Esther Koplowitz institute, IDIBAPS as well as with colleagues in Imperial College which interact in regular teleconference meetings and frequent interchanges. The successful candidate will have a chance to interact with several consortia in which the team participates actively, including ZENCODE, T2DSYSTEMS, HIRN, a collaborative project funded by MaratoTV3, CIBERDEM and CHROME.

Annual Salary is 25800-36000 euros per annum.

Please Submit your application, including a letter of interest, CV, and contacts of two references to Carme Sanahuja csanahuj@clinic.ub.es.

Informal inquiries can be directed to Jorge Ferrer at jferrer@clinic.ub.es or j.ferrer@imperial.ac.uk…

Don't forget to mention Naturejobs when applying.

Employer:Institut d'Investigacio Biomedica August Pi i Sunyer (IDIBAPS)

Website:http://www.idibaps.org

Location:Barcelona, Spain

Expires:February 03, 2017

Job type:Postdoctoral

Salary:$25,000 - $35,000

Qualifications:Postgraduate - Doctorate/PhD

Employment type:Contract

Job hours:Full-time