SCIENCE-JOBS-DE

PhD position Stress-induced epigenetic changes in the brain (Darmstadt, Germany)

The Biology Department of the TU Darmstadt (Darmstadt University of Technology), Germany, invites applications for a

PhD position (DFG-funded project)

in the Stem Cell and Developmental Biology group.
The appointment is for three years.

This is an exciting opportunity to perform research on stress-induced epigenetic changes in the brain. Stressful events can lead to long-lasting disease-relevant changes in brain function (e.g. cognitive impairment, posttraumatic stress disorder) and the epigenetic modulation of gene expression plays a crucial role in the brain’s response to stress. Proteins that bind to methylated DNA and influence chromatin structure and gene expression represent critical molecular links between epigenetic marks and neuronal function. MECP2 acts as such an epigenetic reader and plays an essential role in the regulation of a stress hormone system in the brain.

We are looking for a highly motivated person who is interested in performing research in the field of epigenetic gene expression regulation and molecular neurobiology in a dynamic and young international team.

This project involves a large spectrum of modern methodologies including RNA-seq, ChIP-seq, CRISPR/Cas-mediated genome editing and sophisticated primary cell culture work.

JOB DESCRIPTION
The successful candidate should conduct research projects on stress-induced epigenetic changes in the brain leading to a PhD degree.

REQUIRED QUALIFICATIONS AND EXPERIENCE
A Master degree in a relevant field (e.g. biology, molecular medicine, biochemistry).
Very good molecular methods skills.
Bioinformatics expertise (gene expression analyses, programming skills) is desirable but not obligatory.
Experience with mice/isolation of primary cells is of advantage.
Strong ambition to develop into an independent scientist.
Excellent problem-solving skills.
Excellent communication, organizational and interpersonal skills.

The fulfillment of the research and service requirements attached to this position serve at the same time as fulfillment of the academic requirements for a candidate's doctoral degree.

The TU Darmstadt intends to increase the number of female employees and encourages female candidates to apply. In case of equal qualifications applicants with a degree of disability of at least 50 or equal will be given preference. Wages and salaries are according to the collective agreements on salary scales (TV-TU Darmstadt).

Highly motivated, enthusiastic ad ambitious candidates are invited to send an application including CV, certificates, and names of reference persons to Ulrike Nuber (nuber[at]bio.tu-darmstadt.de).

Application deadline: February 27, 2017

Ulrike Nuber
nuber@bio.tu-darmstadt.de
TU Darmstadt
Darmstadt, Germany

Ansprechpartner: Prof. Ulrike Nuber