Lymph node metastasis has been acknowledged to be the first hallmark of advanced stage malignancies. Identification of leading signaling networks controlling lymphogenic metastasis remains a major challenge. We currently work on the identification and functional assessment of tumor- and stromal-derived factors that influence metastatic behavior.

The aim of the current project is to identify a chemokine expression signature associated with prometastatic properties in cutaneous melanoma and the analysis of prometastatic effects of identified chemokines.
Within the framework of the thesis, the Ph.D. student will employ techniques like immunological and functional assays (cell sprouting, migration, apoptosis, cell cycle analysis, …), flow cytometry, Laser Scan Microscopy, image analysis, expression and purification of recombinant proteins, knockdown, silencing and overexpression of genes in vitro as well as animal models of tumor invasion and metastasis.
The current PhD position is embedded into the vascular biology PhD program of the MUV (http://www.meduniwien.ac.at/hp/phd-vascularbiology/). Salary and benefits follow the rules of the Austrian Science Fund FWF.

Job details

Employer:Medical University Vienna / SERD

Website:http://www.meduniwien.ac.at/d...

Location:Waehringer Guertel 18-20, Vienna, Austria

Expires:September 15, 2013

Job type:PhD Studentship

Salary:Unspecified

Qualifications:Undergraduate - Bachelor's degree

Employment type:Contract

Job hours:Full-time