http://www.nature.com/naturejobs/science

Postdoctoral Researcher - Cell Engineering : Dublin, Ireland

The Animal Cell Biotechnology group at the National Institute for Cellular Biotechnology focus their research on understanding the molecular mechanisms underpinning recombinant protein productivity in Chinese Hamster ovary (CHO) cells. These cells are the dominant platform for the production of Biopharmaceutical drugs, e.g. monoclonal antibodies. By improving the ability of CHO cells to make and secrete these proteins we hope to contribute to reducing their cost.
Specifically we apply ‘omics technologies to discover the networks of genes impacting on CHO cell phenotypes relevant to the bioreactor environment.
Recently much of this focus has been in the area of miRNA biology. These small, non-coding RNA molecules represent a critical regulatory layer within the cell at the post-transcriptional level and have great potential as pathway engineering targets.
The successful candidate will be involved in an exciting, SFI-funded research program implementing cutting edge molecular biology techniques to manipulate the expression of target miRNAs in CHO cells including using targeted genome engineering techniques such as CRISPR/Cas9 technology.
Applicants should have a PhD in Molecular Cellular Biology or related discipline. In addition, it is highly desirable that the candidate has considerable experience in molecular biology techniques including gene cloning, sequence analysis and manipulation. Practical experience with mammalian cell culture would also be considered beneficial. …

Job details

Employer:Dublin City University (DCU)

Website:http://www.nicb.dcu.ie/resear...

Location:Dublin, Ireland

Expires:July 22, 2014

Job type:Postdoctoral

Salary:$40,000 +

Qualifications:Postgraduate - Doctorate/PhD

Employment type:Contract

Job hours:Full-time