In Vivo. 2017 Nov-Dec;31(6):1115-1124.

Mesenchymal Stem Cells Contribute to Improvement of Renal Function in a Canine Kidney Injury Model.

Lee SJ¹, Ryu MO¹, Seo MS², Park SB^3,4, Ahn JO¹, Han SM¹, Kang KS^3,4, Bhang DH⁵, Youn HY⁶.

Abstract

BACKGROUND/AIM:

The kidney excretes waste materials and regulates important metabolic functions, and renal disorders constitute a significant medical problem and can result in fatalities. In the present study, mesenchymal stem cells derived from canine umbilical cord blood (cUCB-MSCs) were isolated and evaluated for their ability to improve renal function in a canine model of acute kidney injury (AKI).

MATERIALS AND METHODS:

The canine AKI model was developed by i.v. injection of cisplatin and gentamycin into 14 male beagle dogs. cUCB-MSCs were administered into the renal corticomedullary junction following AKI induction. Survival time, clinical signs, blood analysis and histological parameters were analyzed.

RESULTS:

The group treated with AKI plus cUCB-MSCs had decreased blood urea nitrogen and creatinine levels, and showed an extended life-span and improved histological manifestations. MSCs were detected around the tubules of these kidneys at the histological level.

CONCLUSION:

Taken together, our findings suggest that cUCB-MSCs could be an alternative therapeutic agent for canine AKI.